| Country | # Multi-Medalists | Athletes |
| USA | 16 |
| PHELPS Michael | Swimming | 6 |
| FRANKLIN Missy | Swimming | 5 |
| SCHMITT Allison | Swimming | 5 |
| LOCHTE Ryan | Swimming | 5 |
| FELIX Allyson | Athletics | 3 |
| VOLLMER Dana | Swimming | 3 |
| ADRIAN Nathan | Swimming | 3 |
| GREVERS Matthew | Swimming | 3 |
| SONI Rebecca | Swimming | 3 |
| RAISMAN Alexandra | Gymnastics | 3 |
| JONES Cullen | Swimming | 3 |
| JETER Carmelita | Athletics | 3 |
| DOUGLAS Gabrielle | Gymnastics | 2 |
| RICHARDS-ROSS Sanya | Athletics | 2 |
| WILLIAMS Serena | Tennis | 2 |
| BERENS Ricky | Swimming | 2 |
|
| China | 9 |
| SUN Yang | Swimming | 4 |
| ZOU Kai | Gymnastics | 3 |
| CHEN Ruolin | Diving | 2 |
| FENG Zhe | Gymnastics | 2 |
| LI Xiaoxia | Table Tennis | 2 |
| WU Minxia | Diving | 2 |
| YE Shiwen | Swimming | 2 |
| ZHANG Jike | Table Tennis | 2 |
| ZHAO Yunlei | Badminton | 2 |
|
| Great Britain | 4 |
| DUJARDIN Charlotte | Equestrian | 5 |
| FARAH Mohamed | Athletics | 3 |
| HOY Chris | Cycling | 3 |
| KENNY Jason | Cycling | 3 |
| TROTT Laura | Cycling | 3 |
|
| Australia | 4 |
| COUTTS Alicia | Swimming | 5 |
| ELMSLIE Brittany | Swimming | 3 |
| SCHLANGER Melanie | Swimming | 3 |
| SEEBOHM Emily | Swimming | 3 |
|
| Russia | 4 |
| MUSTAFINA Aliya | Gymnastics | 4 |
| ISHCHENKO Natalia | Swimming | 2 |
| ROMASHINA Svetlana | Swimming | 2 |
| ANTYUKH, Natalya | Athletics | 2 |
|